Idiopathic Inflammatory Bowel Diseases (IBD), which constitute a major group of diseases of the gastrointestinal tract, are characterized by chronic and recurrent, of immunological origin and unknown etiology inflammation. The two main manifestations of IBD are Crohn's Disease (CD) and Ulcerative Colitis (UC), whose etiology has mechanisms involving both acquired and innate immunity. These are types of autoimmune diseases in which there is a chronic and persistent intestinal inflammation that appears to be correlated with many different factors, such as genetic predisposition, environment, and the composition of the intestinal flora.

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is characterized by uncoordinated contraction, which can potentially lead to thrombus formation, ischemic strokes, even death. Expression differences in genes involved in fibrosis or inflammation can promote cardiac remodeling, which leads to the development and maintenance of atrial fibrillation. However, the underlying molecular mechanisms are still not well understood. Because of this insufficient knowledge of the pathogenic mechanisms of AF, therapeutic strategies are limited to the prevention of its complications, such as stroke, rather than the disease itself. Our aim is to identify new genes that play a critical role in the development of AF and can provide clues to the disease's pathogenic mechanisms but also be used as pharmacological targets to reverse the pathophysiological process behind the disease.

Dilated Cardiomyopathy (DCM) and Ischemic Cardiomyopathy (ICM) are the most common causes of Heart Failure (HF), a syndrome with an estimated prevalence of 64.3 million people worldwide. The aim of the present study is to elucidate the gene signature of DCM and ICM, denoted as DiSig (Dilated cardiomyopathy Signature) and IsSig (Ischemic cardiomyopathy Signature), respectively, through bioinformatic analysis.

COVID-19 is a respiratory infectious disease caused by the prototype coronavirus SARS-CoV-2 and has created a global health crisis. The disease causes a variety of symptoms in patients, ranging from mild cold-like symptoms to severe acute respiratory syndrome and sometimes death. The purpose of the present study is to discover potential drug targets using transcriptomic data from blood and lung.

The intestinal microflora and by extension its genetic material (microbiome) has been associated with a multitude of diseases mainly of immunological and metabolic nature. The intestinal microflora, which is the total number of microorganisms of gastrointestinal tract of the intestine (bacteria, viruses, fungi), seems to be involved in many pathogenic mechanisms of various pathological conditions both of the gastrointestinal tract and of a;; systems in general and has been the subject of extensive research the last years. It is a unique identifier for each person and is influenced by geographical, nutritional, and in general environmental conditions. Nowadays it is considered a symbiotic "organism", providing numerous benefits to the host. Through state-of-the-art bioinformatics approaches our studies attempt to unravel the role of the microbiome during homeostasis and disease.