George C. Kolios

George C. Kolios

MD, PhD, Professor Emeritus of Pharmacology
Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace

Biography

George C. Kolios is a Professor Emeritus of Pharmacology in the Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. He obtained his first degree in Medicine in 1980 from the School of Medicine at the University of Athens, Greece. In 1992, he obtained his PhD degree in Gastroenterology from the School of Medicine at the University of Athens, Greece and in 1998, his PhD degree in Pharmacology from the Department of Pharmacology at the University of Bath, United Kingdom. In 1990, he finished his Specialization in Gastroenterology and he first worked as Registrar in Gastroenterology at the Royal United Hospital, Bath, United Kingdom and then as Senior Registrar in the Gastroenterology Department at the Hippokration General Hospital, Athens, Greece. From 1998 till 2001, he worked as Consultant Gastroenterologist at the Royal United Hospital, Bath, and Senior Research Fellow in the Department of Pharmacology at the University of Bath, United Kingdom. In 2001, he was appointed Assistant Professor of Gastroenterology in the School of Medicine at the University of Crete and Visiting Professor in Pharmacology at the University of Bath, United Kingdom. From 2008 till today, he is Professor of Pharmacology in the School of Medicine at the Democritus University of Thrace, Alexandroupolis, and from 2008 till 2017 he was Director of the laboratory of Pharmacology in the School of Medicine at the Democritus University of Thrace. Greece. From 2008 till 2013, he was Member of the Scientific Board of Approvals of the Greek National Organization for Medicines.  He has organized and directed from 2011 till 2018 the Master's Degree Program "Clinical Pharmacology and Therapeutics" at the School of Medicine of Democritus University of Thrace. From 2015 till today, he is Member of the Pharmacology Department in the Scientific Institute of the Greek General Medical Council, while from 2017 till 2019, he was President of this Board. From 2020 till today, he is Member of the Clinical and Translational Team in the Centre for Therapeutic Innovation at the University of Bath, United Kingdom.

 

Professor Kolios is an experienced Clinical Gastroenterologist, and a very productive research scientist, with an extensive work in the area of immunopharmacology, mucosal immunology and fibrosis, mainly focused on the intestinal inflammation and Inflammatory Bowel Diseases. His work has demonstrated that the mucosal epithelium could be a rich source of various inflammatory mediators, including cytokines, chemokines and nitric oxide, which are involved in inflammation and fibrosis, and that these pro-inflammatory systems can be modified by cytokines derived by T-cell population. In addition, his work has been focused on the biology and the role of gut subepithelial myofibroblasts in fibrosis and on the interplay between gut mucosal immunity and microbiota and the development of in vitro models for the study of mucosal immunology, such as isolation of cells from gut mucosa, cell cultures and development of intestinal organoids from human pluripotent stem cells. He has more than 130 papers in peer reviewed journals with Mean IF: 4,855, which have been cited more than 5800 times with an h-index 40 and more than 250 announcements and invited lectures in scientific congresses in Greece and abroad.

Publications

  1. Karamitrousis E, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, Trypsianis G, Karayiannakis A, Bolanaki H, Chatzaki E, Kolios G, Lianidou E, Lambropoulou M, Kakolyris S. Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer. Clinical Chemistry and Laboratory Medicine . 2020; Online ahead of print. 
  2. Varbobitis I, Kokkotis G, Gizis M, Perlepe N, Laoudi E, Bletsa M, Bekiari D, Koutsounas I, Kounadis G, Xourafas V, Lagou S, Kolios G, Papakonstantinou I, Bamias G. The IBD-F Patient Self-Assessment Scale Accurately Depicts the Level of Fatigue and Predicts a Negative Effect on the Quality of Life of Patients with IBD in Clinical Remission. Inflammatory Bowel Diseases . 2020; Aug 7;izaa201. 
  3. Karatzas E, Zachariou M, Bourdakou MM, Minadakis G, Oulas A, Kolios G, Delis A, Spyrou GM. PathWalks: Identifying pathway communities using a disease-related map of integrated information. Bioinformatics . 2020; 36:4070-4079. 
  4. Koureta M, Karaglani M, Panagopoulou M, Balgkouranidou I, Papadaki-Anastasopoulou A, Zarouchlioti C, Dekavallas S, Kolios G, Lambropoulou M, Baritaki S, Chatzaki E. Corticotropin Releasing Factor Receptors in breast cancer: Expression and activity in hormone-dependent growth in vitro. Peptides . 2020; 129:170316. 
  5. Dovrolis N, Michalopoulos G, Theodoropoulos GE, Arvanitidis K, Kolios G, Sechi LA, Eliopoulos AG, Gazouli M. The Interplay between Mucosal Microbiota Composition and Host Gene-Expression is Linked with Infliximab Response in Inflammatory Bowel Diseases. Microorganisms . 2020; 8:438. 
  6. Gogou M, Kolios G. Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone? Journal of the American College of Nutrition . 2020; 39:261-271.
  7. Karaglani M, Tzitzikou E, Tottas S, Kougioumtzis I, Arvanitidis K, Kolios G, Chatzaki E, Drosos GI. Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations. Journal of Orthopaedics . 2019; 19:9-13. 
  8. Papaioannou VE, Sertaridou EN, Chouvarda IG, Kolios GC, Pneumatikos IN. Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study. Intensive Care Medicine Experimental . 2019; 7:53. 
  9. Karatzas E, Minadakis G, Kolios G, Delis A, Spyrou GM. A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria. Computational and Structural Biotechnology Journal . 2019; 17:939-945. 
  10. Mantziaris V, Kolios G. Gut Microbiota, Atherosclerosis, and Therapeutic Targets. Critical Pathways in Cardiology . 2019; 18:139-142. 
    Panagopoulou M, Karaglani M, Balgkouranidou I, Biziota E, Koukaki T, Karamitrousis E, Nena E, Tsamardinos I, Kolios G, Lianidou E, Kakolyris S, Chatzaki E. Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers. Oncogene . 2019; 38:3387-3401. 
  11.  Paspaliaris V, Kolios G. Stem cells in Osteoporosis: From Biology to New Therapeutic Approaches. Stem Cells International . 2019; 1730978:1-16. 
  12.  Gazouli M, Dovrolis N, Franke A, Spyrou GM, Sechi LA, Kolios G. Differential genetic and functional background in inflammatory bowel disease phenotypes of a Greek population: a systems bioinformatics approach. Gut Pathogens . 2019; 11:31. 
  13.  Dovrolis N, Filidou E, Kolios G. Systems biology in inflammatory bowel diseases: on the way to precision medicine. Annals of Gastroenterology . 2019; 32:233-246. 
  14.  Valatas V, Kolios G, Bamias G. GTL1A (TNFSF15) and DR3 (TNFRSF25): a co-stimulatory system of cytokines with diverse functions in gut mucosal immunity. Frontiers in Immunology . 2019; 10:583. 
  15.  Karaglani M, Ragia G, Panagopoulou M, Balgkouranidou I, Nena E, Kolios G, Papanas N, Manolopoulos VG, Chatzaki E. Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment. Experimental and Clinical Endocrinology & Diabetes . 2019; 25:217-225. 
  16.  Dovrolis N, Kolios G, Spyrou GM, Maroulakou I. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics . 2019; 20:825-841. 
  17.  Dovrolis N, Drygiannakis I, Filidou E, Kandilogiannakis L, Arvanitidis K, Tentes I, Kolios G, Valatas V. Gut Microbial Signatures Underline Complicated Crohn's Disease but Vary Between Cohorts; An in Silico Approach. Inflammatory Bowel Diseases . 2019; 25:217-225. 
  18.  Panagopoulou M, Karaglani M, Balgkouranidou I, Pantazi C, Kolios G, Kakolyris S, Chatzaki E. Circulating cell-free DNA release in vitro: kinetics, size profiling, and cancer-related gene methylation. Journal of Cellular Physiology . 2019; 234:14079-14089. 
  19.  Tsaousi G, Stavrou G, Fotiadis K, Kotzampassi K, Kolios G. Implementation of phospholipids as pharmacological modalities for postoperative adhesions prevention. European Journal of Pharmacology . 2019; 842:189-196. 
    Karatzas E, Kolios G, Spyrou GM. An Application of Computational Drug Repurposing Based on Transcriptomic Signatures. Methods in Molecular Biology . 2019; 1903:149-177. 
    Tsekoura M, Ioannidou M, Pana ZD, Haidich AB, Antachopoulos C, Iosifidis E, Kolios G, Roilides E. Efficacy and Safety of Echinocandins for the Treatment of Invasive Candidiasis in Children: A Meta-analysis. Pediatric Infectious Disease Journal . 2019; 38:42-49. 
  20.  Sertaridou EN, Chouvarda IG, Arvanitidis KI, Filidou EK, Kolios GC, Pnevmatikos IN, Papaioannou VE. Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study. Annals of Intensive Care . 2018; 8:118. 
  21. Fasoulakis Z, Kolios G, Papamanolis V, Kontomanolis EN. Interleukins Associated with Breast Cancer. Cureus . 2018; 10:e3549. 
  22. Ioannidis A, Arvanitidis K, Filidou E, Valatas V, Stavrou G, Michalopoulos A, Kolios G, Kotzampassi K. The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction. Journal of the Society of Laparoendoscopic Surgeons . 2018; 22. pii: e2018.00045. 
  23.  Filidou E, Valatas V, Drygiannakis I, Arvanitidis K, Vradelis S, Kouklakis G, Kolios G, Bamias G. Cytokine Receptor Profiling in Human Colonic Subepithelial Myofibroblasts: A Differential Effect of Th Polarization-Associated Cytokines in Intestinal Fibrosis. Inflammatory Bowel Diseases . 2018; 24:2224-2241. 
  24.  Stavrou G, Arvanitidis K, Filidou E, Fotiadis K, Grosomanidis V, Ioannidis A, Tsaousi G, Michalopoulos A, Kolios G, Kotzampassi K. Combined Enteral and Parenteral Glutamine Supplementation in Endotoxaemic Swine: Effects on Portal and Systemic Circulation Levels. Medical Principles and Practice . 2018; 27:570-578. 
  25.  Papavramidis TS, Stavrou G, Papakostas P, Grosomanidis V, Kokkota S, Michalopoulos A, Kolios G, Kotzampassi K. Displacement of the Intragastric Balloon from the Fundus to the Antrum Results in Enhanced Weight Loss. Obesity Surgery . 2018; 28:2374-2378. 
  26.  Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA. Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study. Clinical Pharmacology and Therapeutics . 2018; 104:317-325. 
  27. Gogou M, Kolios G. Are therapeutic diets an emerging additional choice in autism spectrum disorder management? World Journal of Pediatrics . 2018; 14:215-223. 
    Karaglani M, Ragia G, Panagopoulou M, Balgkouranidou I, Nena E, Kolios G, Papanas N, Manolopoulos VG, Chatzaki E. Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment. Experimental and Clinical Endocrinology & Diabetes . 2018; doi: 10.1055/s-0043-121265. 
  28. Dovrolis N, Kolios G, Spyrou GM, Maroulakou I. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics . 2017; doi: 10.1093/bib/bbx154. 
    Karatzas E, Bourdakou MM, Kolios G, Spyrou GM. Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score. Scientific Reports . 2017; 7:12569. 
  29.  Bouros E, Filidou E, Arvanitidis K, Mikroulis D, Steiropoulos P, Bamias G, Bouros D, Kolios G. Lung fibrosis-associated soluble mediators and bronchoalveolar lavage from idiopathic pulmonary fibrosis patients promote the expression of fibrogenic factors in subepithelial lung myofibroblasts. Pulmonary Pharmacology & Therapeutics 2017; 46:78-87. 
  30. Gogou M, Kolios G. The effect of dietary supplements on clinical aspects of autism spectrum disorder: A systematic review of the literature. Brain & Development . 2017; 39:656-664.
  31. Dovrolis N, Kolios G, Spyrou G, Maroulakou I. Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases. Drug Discovery Today . 2017; 22:805-813. 
    Valatas V, Filidou E, Drygiannakis I, Kolios G. Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface. Annals of Gastroenterology . 2017; 30:393-404. 
  32.  Panagopoulou M, Lambropoulou M, Balgkouranidou I, Nena E, Karaglani M, Nicolaidou C, Asimaki A, Konstantinidis T, Constantinidis TC, Kolios G, Kakolyris S, Agorastos T, Chatzaki E. Gene promoter methylation and protein expression of BRMS1 in uterine cervix in relation to high-risk human papilloma virus infection and cancer. Tumour Biology . 2017; 39:1010428317697557. 
  33.  Bamias G, Filidou E, Goukos D, Valatas V, Arvanitidis K, Panagopoulou M, Kouklakis G, Daikos GL, Ladas SD, Kolios G. Crohn's disease-associated mucosal factors regulate the expression of TNF-like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells. Translational Research . 2017; 180:118-130.e2. 
  34.  Kotanidis L, Nikolettos K, Petousis S, Asimakopoulos B, Chatzimitrou E, Kolios G, Nikolettos N. The use of serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) to predict the number of oocytes collected and availability of embryos for cryopreservation in IVF. Journal of Endocrinological Investigation . 2016; 39:1459-1464. 
  35. Kolios G Animal models of inflammatory bowel disease: how useful are they really? Current Opinion in Gastroenterology . 2016; 32:251-257.
    Kolios G . Bin1 Antibodies for IBD Therapy: Is Permeability the Answer BAR None? Digestive Diseases and Sciences . 2016; 61:330-331.

Phone
25510 30541
Email
emanolop@med.duth.gr
Address

Laboratory of Pharmacology
preclinical Buildings
Dragana, 68100 Alexandroupolis

Funding

Project no.82601 was implemented within the framework of the Action "Creation of a Center of Excellence for Pharmacological Studies and Precision Medicine" (MIS 5047189) which is part of the Action "Supporting Regional Excellence" and is financed by the Operational Program "Competitiveness, Entrepreneurship and Innovation" within the framework of the NSRF 2014 -2020, co-financed by Greece and the European Union (European Regional Development Fund)

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